What are the novel findings of this work?
In twin pregnancies undergoing chorionic villus sampling (CVS), compared to those not undergoing CVS, there is a 2-fold increased risk of fetal loss at <24 weeks’ gestation and loss at any stage in pregnancy. The factors providing a significant independent contribution to the prediction of miscarriage or fetal loss in twin pregnancy are increased maternal weight, black racial origin, monochorionicity,
large intertwin discordance in crown–rump length and increased fetal nuchal translucency thickness.
What are the clinical implications of this work?
The 2-fold increased risk of fetal loss following CVS in twin pregnancy can, to a great extent, be explained by maternal and pregnancy characteristics rather than the invasive procedure itself.